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KMID : 0371319950480050611
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Journal of the Korean Surgical Society
1995 Volume.48 No. 5 p.611 ~ p.630
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The Effects of Drug Interruption on the Septic Process in Peritonitis-Induced Rats
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Abstract
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The increased understanding of pathogenesis of sepsis enable to develop therapeutic modalities which interrupt cellular and humoral cascades associated with septic process. In order to investigate the effects of the drug interrutption on the
septic
process, we conducted this study.Sepsis was induced by cecal ligation and two-site needle punctures. A Sham-operation was performed on ten rats for normal control. The sepsis-induced group was divided into three groups of 15 rats each. The first
group(sepsis group) received no specific treatment. The second group received dexamethasone and amrinone to suppress TNF synthesis and expressed as A treatment group. The other group received pentoxifylline and nonsteroidal antiinflammatory
drug(NSAID)
to suppress the activation of neutrophils and platelets and to inhibit the synthesis of eicosanoids and expressed as B treatment group. After 24 hours, all animals were sacrificed and submitted for the study of werologic and histologic changes.
The
level of tumor necrosis factor was significantly decreased in both treatment groups compared to sepsis group (p<0.01). The level of arterial ketone body ratio was significantly icreased in the B treatment group compared to sepsis and A treatment
groups(p<0.01). the level of serum lactate revealed that B treatment group is better than A treatment group (p<0.05), but both groups showed remarkable improvement when compared to sepsis group(p<0.01). Glutathione content in liver tissue was
significantly increased in the B treatment group compared to that of sepsis group. Microscopic tissue examinations revealed that neutrophilic infiltration and microvascular congestion was found in sepsis group, but in both treatment groups,
neutrophilic
infiltration or microvascular congestion was much decreased.
From these results, the beneficial effects of pentoxifylline and NSAID on the systemic response and organ damage during sepsis were noted.
Although the combination therapy of dexamethasone and amrinone was effective in suppression of TNF synthesis this therapy appeared less effective than that of pentoxifylline and NSAID in the aspects of the suppression of systemic inflammatory
responses
during sepsis.
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KEYWORD
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